Michael Z. Lin

Michael Z. Lin
Rayuwa
Haihuwa	Taipei, 1973 (50/51 shekaru)
Karatu
Makaranta	UCLA David Geffen School of Medicine (en) ; (15 ga Yuni, 1994 - 15 ga Yuni, 2004) Doctor of Medicine (en)
Sana'a
Sana'a	researcher (en) , biologist (en) da chemist (en)
Employers	Jami'ar Stanford (1 Mayu 2009 -

Michael Z. Lin (an haife shi a shekara ta alif 1973) a Taipei, a ƙasar Taiwan) ɗan Taiwan-Ba-Amurke masanin ilimin halittu ne kuma injiniyan halittu. Shi mataimakin Farfesa ne na Neurobiology da Bioengineering a Jami'ar Stanford. An fi saninsa da aikin injiniyanci na gani da ido da sunadarai masu sinadarai.

Ilimi da aiki

Lin ya kammala karatu daga Jami'ar Harvard a 1994 tare da digiri a cikin ilimin kimiyyar halittu summa cum laude.^[1] Daga baya ya horar da shi a matsayin dalibi na PhD yana nazarin fassarar siginar neuronal tare da Michael E. Greenberg a Makarantar Kiwon Lafiya ta Harvard, ya kammala karatunsa a 2002,^[2] kuma ya sami MD a UCLA a 2004. ^[3] Daga nan Lin ya yi bincike na gaba da digiri tare da Chemistry Nobel Prize Laureate Roger Y. Tsien a UCSD.^[4] Tun 2009, ya kasance memba na baiwa a Makarantar Magunguna ta Jami'ar Stanford.

Bincike

A lokacin horo na postdoctoral tare da Roger Y. Tsin, Lin ya haɓaka ingantattun sunadaran sunadaran ja^[5] ^[6] da channelrhodopsins, ^[7] kuma ya fara yin amfani da magungunan miyagun ƙwayoyi don gyare-gyaren furotin a cikin hanyar lakabin furotin TimeSTAMP. Rukunin Lin a Jami'ar Stanford sun ƙera sunadaran sunadaran tare da sabbin ayyuka don optogenetics, chemogenetics, da ilimin halitta na roba. Fitattun abubuwan ƙirƙira sun haɗa da:

Red fluorescent da sunadaran bioluminescent ^[8] ^[9]
Sunadaran da za'a iya canzawa ta gani ta amfani da ingin ingin sunadaran furotin mai kyalli ^[10] ^[11]
Iyali mai nuna alamar wutar lantarki ta asali ta ASAP ^[12] ^[13]
Sarrafa sinadarai na bayanin furotin ta hanyar ƙwayoyin cuta na RNA ^[14] ^[15]
Sunadaran roba waɗanda ke sake dawo da siginar cutar kansa zuwa kunnawar warkewa ^[16] ^[17]
SARS-CoV-2 protease inhibitors dangane da gyara HCV protease inhibitors ^[18]

Kyaututtuka da karramawa

Kudin hannun jari Burroughs Wellcome Fund Kyauta a Kimiyyar Kiwon Lafiya (2007) ^[19]
Kyautar Majagaba ta Cibiyar Kiwon Lafiya ta Ƙasa (2013)
Masanin Gidauniyar Rita Allen (2016) ^[20]
Ƙungiyar Hoto Kwayoyin Halitta ta Duniya Roger Tsien Awardee don Ƙwarewa a Ilimin Sinadarai (2019) ^[21]

Manazarta

↑ "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.
↑ "Chemistry Tree - Michael Z. Lin". academictree.org.
↑ "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.
↑ "Chemistry Tree - Michael Z. Lin". academictree.org.
↑ Shaner, N. C.; Lin, M. Z.; McKeown, M. R.; Steinbach, P. A.; Hazelwood, K. L.; Davidson, M. W.; Tsien, R. Y. (2008). "Improving the photostability of bright monomeric orange and red fluorescent proteins". Nature Methods. 5 (6): 545–51. doi:10.1038/nmeth.1209. PMC 2853173. PMID 18454154
↑ Empty citation (help)
↑ Lin, J. Y.; Lin, M. Z.; Steinbach, P.; Tsien, R. Y. (2009). "Characterization of engineered channelrhodopsin variants with improved properties and kinetics". Biophysical Journal. 96 (5): 1803–14. Bibcode:2009BpJ....96.1803L. doi:10.1016/j.bpj.2008.11.034. PMC 2717302. PMID 19254539
↑ Chu, J.; Oh, Y.; Sens, A.; Ataie, N.; Dana, H.; MacKlin, J. J.; Laviv, T.; Welf, E. S.; Dean, K. M.; Zhang, F.; Kim, B. B.; Tang, C. T.; Hu, M.; Baird, M. A.; Davidson, M. W.; Kay, M. A.; Fiolka, R.; Yasuda, R.; Kim, D. S.; Ng, H. L.; Lin, M. Z. (2016). "A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo". Nature Biotechnology. 34 (7): 760–7. doi:10.1038/nbt.3550. PMC 4942401. PMID 27240196
↑ Gitig, Diana (9 November 2016). "Watching a cell cycle". Ars Technica
↑ "Phosphorylation at the Flick of a Switch". The Scientist Magazine
↑ Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577
↑ Vogt, Nina (January 2020). "RAMPing up voltage indicator imaging". Nature Methods. 17 (1): 25. doi:10.1038/s41592-019-0720-4. PMID 31907465. S2CID 209897141
↑ Villette, V; Chavarha, M; Dimov, IK; Bradley, J; Pradhan, L; Mathieu, B; Evans, SW; Chamberland, S; Shi, D; Yang, R; Kim, BB; Ayon, A; Jalil, A; St-Pierre, F; Schnitzer, MJ; Bi, G; Toth, K; Ding, J; Dieudonné, S; Lin, MZ (12 December 2019). "Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice". Cell. 179 (7): 1590–1608.e23. doi:10.1016/j.cell.2019.11.004. PMC 6941988. PMID 31835034
↑ Chung, H. K.; Jacobs, C. L.; Huo, Y.; Yang, J.; Krumm, S. A.; Plemper, R. K.; Tsien, R. Y.; Lin, M. Z. (2015). "Tunable and reversible drug control of protein production via a self-excising degron". Nature Chemical Biology. 11 (9): 713–20. doi:10.1038/nchembio.1869. PMC 4543534. PMID 26214256
↑ Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496
↑ Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496
↑ Chung, HK; Zou, X; Bajar, BT; Brand, VR; Huo, Y; Alcudia, JF; Ferrell JE, Jr; Lin, MZ (3 May 2019). "A compact synthetic pathway rewires cancer signaling to therapeutic effector release". Science. 364 (6439): eaat6982. doi:10.1126/science.aat6982. PMC 7053279. PMID 31048459
↑ Westberg, Michael; Su, Yichi; Zou, Xinzhi; Ning, Lin; Hurst, Brett; Tarbet, Bart; Lin, Michael Z. (2020-09-16). "Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases". bioRxiv: 2020.09.15.275891. doi:10.1101/2020.09.15.275891. S2CID 221823586
↑ "2011-2007 Awardees | Burroughs Wellcome Fund". www.bwfund.org
↑ "Michael Lin". Rita Allen Foundation.
↑ "World Molecular Imaging Society Announces Early Stage Awardees for 2019". World Molecular Imaging Society. 12 September 2019.

[1] "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.

[2] "Chemistry Tree - Michael Z. Lin". academictree.org.

[3] "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.

[4] "Chemistry Tree - Michael Z. Lin". academictree.org.

[5] Shaner, N. C.; Lin, M. Z.; McKeown, M. R.; Steinbach, P. A.; Hazelwood, K. L.; Davidson, M. W.; Tsien, R. Y. (2008). "Improving the photostability of bright monomeric orange and red fluorescent proteins". Nature Methods. 5 (6): 545–51. doi:10.1038/nmeth.1209. PMC 2853173. PMID 18454154

[6] Empty citation (help)

[7] Lin, J. Y.; Lin, M. Z.; Steinbach, P.; Tsien, R. Y. (2009). "Characterization of engineered channelrhodopsin variants with improved properties and kinetics". Biophysical Journal. 96 (5): 1803–14. Bibcode:2009BpJ....96.1803L. doi:10.1016/j.bpj.2008.11.034. PMC 2717302. PMID 19254539

[8] Chu, J.; Oh, Y.; Sens, A.; Ataie, N.; Dana, H.; MacKlin, J. J.; Laviv, T.; Welf, E. S.; Dean, K. M.; Zhang, F.; Kim, B. B.; Tang, C. T.; Hu, M.; Baird, M. A.; Davidson, M. W.; Kay, M. A.; Fiolka, R.; Yasuda, R.; Kim, D. S.; Ng, H. L.; Lin, M. Z. (2016). "A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo". Nature Biotechnology. 34 (7): 760–7. doi:10.1038/nbt.3550. PMC 4942401. PMID 27240196

[9] Gitig, Diana (9 November 2016). "Watching a cell cycle". Ars Technica

[10] "Phosphorylation at the Flick of a Switch". The Scientist Magazine

[11] Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577

[12] Vogt, Nina (January 2020). "RAMPing up voltage indicator imaging". Nature Methods. 17 (1): 25. doi:10.1038/s41592-019-0720-4. PMID 31907465. S2CID 209897141

[13] Villette, V; Chavarha, M; Dimov, IK; Bradley, J; Pradhan, L; Mathieu, B; Evans, SW; Chamberland, S; Shi, D; Yang, R; Kim, BB; Ayon, A; Jalil, A; St-Pierre, F; Schnitzer, MJ; Bi, G; Toth, K; Ding, J; Dieudonné, S; Lin, MZ (12 December 2019). "Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice". Cell. 179 (7): 1590–1608.e23. doi:10.1016/j.cell.2019.11.004. PMC 6941988. PMID 31835034

[14] Chung, H. K.; Jacobs, C. L.; Huo, Y.; Yang, J.; Krumm, S. A.; Plemper, R. K.; Tsien, R. Y.; Lin, M. Z. (2015). "Tunable and reversible drug control of protein production via a self-excising degron". Nature Chemical Biology. 11 (9): 713–20. doi:10.1038/nchembio.1869. PMC 4543534. PMID 26214256

[15] Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496

[16] Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496

[17] Chung, HK; Zou, X; Bajar, BT; Brand, VR; Huo, Y; Alcudia, JF; Ferrell JE, Jr; Lin, MZ (3 May 2019). "A compact synthetic pathway rewires cancer signaling to therapeutic effector release". Science. 364 (6439): eaat6982. doi:10.1126/science.aat6982. PMC 7053279. PMID 31048459

[18] Westberg, Michael; Su, Yichi; Zou, Xinzhi; Ning, Lin; Hurst, Brett; Tarbet, Bart; Lin, Michael Z. (2020-09-16). "Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases". bioRxiv: 2020.09.15.275891. doi:10.1101/2020.09.15.275891. S2CID 221823586

[19] "2011-2007 Awardees | Burroughs Wellcome Fund". www.bwfund.org

[20] "Michael Lin". Rita Allen Foundation.

[21] "World Molecular Imaging Society Announces Early Stage Awardees for 2019". World Molecular Imaging Society. 12 September 2019.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]