Mercedes-Benz W220 S500, wanda aka samar daga shekarar alif dubu daya da dari tara da casa'in da takwas 1998 zuwa shekarar alif dubu biyu da biyar 2005, ya kasance babban bambance-bambancen sinadaren alatu na S-Class, yana ba da gauraya na sophistication da aiki. W220 S500 ya fito da tsari mai sumul kuma mai iska, yana nuna jajircewar Mercedes-Benz ga ƙaya mara lokaci. A ciki, S500 ya ba da ƙaƙƙarfan ciki da fasaha, yana ba da yanayin tuki mai daɗi da kwanciyar hankali. An yi amfani da S500 ta injin V8 mai nauyin lita biyar 5.0, yana ba da aiki mai santsi da iko. An girmama shi don ƙaƙƙarfan alƙawuransa da ingantattun kuzarin tuki, S500 ya saita ma'auni don manyan sedans na zartarwa.

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